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Speaker Series Semester Darwin Day 2017

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"Molecular Evolution, Systems Biology and Precision Medicine""Molecular Evolution, Systems Biology and Precision Medicine"<img alt="" src="/darwin-day-sub-site/PublishingImages/Darwin%20Day%202017/Cathy%20WU.png" style="BORDER:0px solid;" /><p>​Dr. Cathy Wu is the Edward G. Jefferson Chair and Director of the Center for Bioinformatics & Computational Biology (CBCB) at the University of Delaware. She has conducted bioinformatics and computational biology research for 25 years and has led or co-led several large multi-institutional Consortium grant projects funded by NIH, NSF and DOE. As the Director of the Protein Information Resource (PIR), Dr. Wu co-founded the international UniProt Consortium in 2002, which has become a central hub for protein sequence and function with about 5 million page views per month from over 500,000 unique sites worldwide. Recognized as a “Highly Cited Researcher” (top 1%) by Thomson Reuters, she has published about 250 peer-reviewed papers, with over 21,800 citations and an h-index of 50. Her research encompasses genomic and protein annotation, biomedical text mining and ontology, systems biology, big data analytics, and translational bioinformatics. The CBCB she established fosters multidisciplinary research collaborations, serves as the home of the UD Bioinformatics Master’s and PhD degree programs, and provides cutting-edge bioinformatics infrastructure, including Big Data and clinical genomics analytics capabilities for precision medicine.</p>2017-02-13T05:00:00Z<p>​<strong>Abstract:</strong>“There is a tremendous amount of information regarding the evolutionary history and biochemical function implicit in each sequence and the number of known sequences is growing explosively” (Margaret Dayhoff, 1967). The Atlas of Protein Sequence and Structure and the probability model of protein evolution formulated by Dayhoff has laid the foundation for modern day bioinformatics. With the advent of next-generation sequencing (NGS) and other high-throughput omics technologies, systems integration is becoming the driving force for the 21st century biology and medicine. This talk will highlight bioinformatics collaborative projects in systems biology and genomic medicine being conducted at the Protein Information Resource (PIR) and the Center for Bioinformatics & Computational Biology (CBCB)—tracing its root to the Atlas and the PIR Protein Sequence Database.</p>

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